Drugs suspected to be involved in the DDI
Complete list of drugs taken by the patient
Cimicifuga, echinacea, licorice, giner, perilla, vitD3
Clinical case description
Patient taking Triumeq plus different alternative medicines including zinc suplements. Potential interaction between zinc and Triumeq. It was recommended to take the supplements and the rest of complementary treatments separately 12h from Triumeq.
Coadministration may decrease dolutegravir concentrations due to complex binding to polyvalent ions (chelation). It is recommended to administer dolutegravir 2 hours before or 6 hours after taking the supplements containing polyvalent cations. Although the magnitude of the decrease in doluteravir concentrations may be ameliorated by taking dolutegravir and supplements together with food, there no data on zinc supplements specifically.