Date of report 22 Jun 2020
Reported case interaction between
Cobicistat and PALIPERIDONE
Cobicistat and PALIPERIDONE
Drugs suspected to be involved in the DDI
Complete list of drugs taken by the patient
Paliperidone 12mg/d Lorazepam 5mg/d Mirtazapine 30mg/d Levomepromazin 25 mg/d
Clinical case description
50-year-old HIV positive patient. Multiple virological failures with multi-drug resistant HIV strain, and reduced ARV options. Undetectable on DRV/c + dolutegravir. Clinical history relevant for chronic delusional syndrome treated orally by paliperidone, levomepromazin, mirtazapine and lorazepam. Admitted to psiquiatry depertment due to acute psychotic decompensation. The patient refused oral medication, so intramuscular paliperidone was chosen. The patient received paliperidone 150mg IM at admission, and 100mg IM 4 days later. Clinical response was appropriate, without evidence of paliperidone toxicity. Although paliperidone is primarily eliminated renally, with minimal metabolism occurring via CYP2D6 and CYP3A4, a high IM dose combined with Darunavir/cobicistat could potentially increase paliperidone exposure, and lead to side effects, but they were not seen in our case.
Clinical Outcome
Editorial Comment
This case reveals no unexpected side effects between darunavir/cobicistat and paliperidone. The dose chosen is in the lower rank of the dose recommendation. Interestingly QTc interval monitoring should be recommended in those patients as a potential severe side effect.
University of Liverpool Recommendation
Potential interaction likely to be of weak intensity. Additional action/monitoring or dosage adjustment is unlikely to be required