Real-world HIV clinical cases involving
drug-drug interactions

Bictegravir – Rifabutin

Clinical implications of rifamycin-induced drug interactions in integrase inhibitor–based ART

This case highlights several key aspects: the clinical relevance of induction effects on integrase inhibitors, the limitations of unvalidated dose-adjustment strategies, and the value of therapeutic drug monitoring (TDM) in guiding individualized treatment decisions. Long-term follow-up, combined with close pharmacokinetic and virologic monitoring, will be essential to confirm the broader applicability of this approach in clinical practice.