Date of report 10 Dec 2019
Reported case interaction between
Ritonavir and Nebivolol
Ritonavir and Nebivolol
Drugs suspected to be involved in the DDI-summary
Complete list of drugs taken by the patient
Nebivolol, VIII factor
Clinical case description
49-year-old man with history of hemophilia A, HIV infection diagnosed in 1990 and HCV infection, achieving sustained virologic response after treatment. Highly ART-experienced, currently on ART with TDF/FTC (300/200 mg qd) + DRV/r (600/100 mg bid) + RAL (400 mg bid) since 2016. Undetectable viral load, CD4+ T cells 790/mm3. His cardiologist prescribed nebivolol 2.5 mg qd a year ago due to hypertension and the dose was further increased up to 5 mg qd. Although coadministration of darunavir + ritonavir with nebivolol has not been studied we could expect an increase in nebivolol concentrations due to CYP2D6 metabolism of this drug. The patient has been receiving DRV/r and nebivolol for a year with successful control of blood pressure and no evidence of adverse effects.
Clinical Outcome
Editorial Comment
This case represents a common situation in clinical practice in which two drugs could have a theoretical weak interaction but no clinical impact is found in real life experience.