Date of report 10 Dec 2019
Reported case interaction between
Ritonavir and Nebivolol
Ritonavir and Nebivolol
Drugs suspected to be involved in the DDI
Complete list of drugs taken by the patient
Nebivolol, VIII factor
Clinical case description
49-year-old man with history of hemophilia A, HIV infection diagnosed in 1990 and HCV infection, achieving sustained virologic response after treatment. Highly ART-experienced, currently on ART with TDF/FTC (300/200 mg qd) + DRV/r (600/100 mg bid) + RAL (400 mg bid) since 2016. Undetectable viral load, CD4+ T cells 790/mm3. His cardiologist prescribed nebivolol 2.5 mg qd a year ago due to hypertension and the dose was further increased up to 5 mg qd. Although coadministration of darunavir + ritonavir with nebivolol has not been studied we could expect an increase in nebivolol concentrations due to CYP2D6 metabolism of this drug. The patient has been receiving DRV/r and nebivolol for a year with successful control of blood pressure and no evidence of adverse effects.
Clinical Outcome
Editorial Comment
This case represents a common situation in clinical practice in which two drugs could have a theoretical weak interaction but no clinical impact is found in real life experience.