Drugs suspected to be involved in the DDI-summary
Complete list of drugs taken by the patient
Clinical case description
Clopidogrel is a prodrug that is converted to its active metabolites via CYPs 3A4, 2B6, 2C19 and 1A2. Administration of clopidogrel with potent CYP3A4 inhibitors decreases the AUC and Cmax of clopidogrel’s active metabolite, leading to insufficient inhibition of platelet aggregation. The same may be applied to etravirine, possibly due to inhibition of CYP2C19. Coadministration of clopidogrel and raltegravir has not been studied, but based on metabolism and clearance a clinically significant interaction is unlikely.